The dynamic basis of G-protein recognition and activation by a GPCR - Nature

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10228-wConventional and time-resolved cryo-electron microscopy reveal how NTSR1 dynamically engages and releases different G proteins...

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The dynamic basis of G-protein recognition and activation by a GPCR - Nature

Source: Nature

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10228-wConventional and time-resolved cryo-electron microscopy reveal how NTSR1 dynamically engages and releases different G proteins, capturing over 20 intermediates and uncovering key mechanistic steps in GDP- and GTP-driven activation, subtype selectivity and distinct dissociation pathways.