Intestinal interoceptive dysfunction drives age-associated cognitive decline - Nature

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10191-6Age-related microbiome changes increase medium-chain fatty acid-producing bacteria, driving GPR84-mediated myeloid inflammation, impaired vagal signalling and hippocampal dysfunction; targeting this gut–brain pathway restores memory in aged mice.